| Case |
Site |
Epi or
Conv |
FISH for EGFR |
FISH for MET |
AKT |
ckit |
Vascular Markers |
Cyto- |
Ki67 |
| Ratio |
%Hyper |
%Mono |
Ratio |
%Hyper |
%Mono |
keratins |
| 1 |
Soft tissue met |
Epi |
1 |
0 |
|
1.01 |
16.60% |
|
M,D + |
Neg |
CD31 F+; CD34 F+; Ulex- |
panCK-; CAM5.2- |
10-50% |
| 2 |
Penis |
Epi |
1.03 |
1.60% |
|
1.03 |
0 |
|
S,D + |
Neg |
CD31 +; CD34 -; Ulex+; FVIII+ |
CAM5.2 focal +; panCK focal + |
10-50% |
| Tibia |
Decalcified specimen –FISH not done |
Decalcified specimen – FISH not done |
>50% |
| 3 |
AbdosubQ |
Epi |
1.71 |
1.60% |
52.50% |
1.13 |
16.60% |
|
S,D + |
Neg |
CD31 F+ CD34 F+; D2-40 F+ |
panCK- |
10-50% |
| 4 |
Native Kidney |
Conv |
1.01 |
13.30% |
|
1.03 |
10% |
|
W,F+ |
Neg |
CD31+; CD34+; FVIII |
panCK- |
<10% |
| 5 |
LE |
Epi |
1 |
4.60% |
|
1.18 |
3% |
|
M,D + |
Neg |
CD31+; CD34-; D2-40-; FVIII- |
AE1/3+ |
<10% |
| 6 |
AbdosubQ (1°); |
Conv |
0.99 |
24.60% |
|
Not done |
|
|
W,D + |
Neg |
CD31+; CD34+; D2-40-; FVIII+ |
AE1/3- |
10-50% |
| LE (recur) |
1.07 |
30.30% |
|
0.96 |
10% |
|
M,D + |
Neg |
Not done |
10-50% |
| 7 |
Scalp |
Conv |
1.09 |
25.40% |
|
1.02 |
59.30% |
|
M,D + |
Neg |
CD31+; CD34-; FVIII+ |
panCK- |
>50% |
| 8 |
Scalp (1°); |
Epi |
0.96 |
5.00% |
|
1.16 |
16.60% |
|
Not done |
Neg |
CD31 F+; CD34 F+; FVIII+; Ulex+ |
panCK- |
>50% |
| Scalp (recur) |
Conv |
1 |
0 |
|
Not done |
|
|
M,D + |
Neg |
CD31+, CD34+, FVIII+ |
Not done |
>50% |
| 9 |
LE (1°); |
Epi |
1.06 |
3.30% |
50.80% |
0.93 |
0 |
|
S,D + |
Neg |
CD31 F+; CD34 F+; FVIII+ |
AE1/3+ |
10-50% |
| LE (recur) |
1.02 |
0 |
|
Not done |
|
|
M, D + |
Neg |
| 10 |
LE (1°) |
Epi |
1.02 |
3.30% |
|
1 |
0 |
|
S,D + |
Neg |
CD31+; CD34 F+; Ulex+; |
panCK- |
<10% |
| 11 |
Breast |
Conv |
1.03 |
3.30% |
|
0.98 |
6% |
|
M,D + |
Neg |
CD31+; CD34+; Ulex+ |
AE1/3- |
>50% |
| 12 |
Scalp (1°) |
Conv |
1.04 |
36.10% |
|
0.93 |
0 |
|
S,D + |
Neg |
CD31+; CD34+; FVIII+ |
panCK- |
<10% |
| Scalp (recur) |
1.01 |
0 |
|
Not done |
|
|
M,D + |
Neg |
CD31+; CD34+; FVIII+ |
panCK- |
<10% |
| 13 |
Scalp (1°) |
Conv |
1.02 |
0 |
50.00% |
0.93 |
0 |
|
M,F + |
Neg |
CD31+; CD34+; FVIII+; D2-40+ |
panCK- |
10-50% |
| 14 |
Cheek mucosa (1°) |
Conv |
1.08 |
11.90% |
|
0.95 |
0 |
|
W,F + |
Neg |
CD31+, CD34+; FVIII+; D2-40+ |
panCK- |
<10% |
| 15 |
LE (1°) |
Epi |
1.02 |
45.00% |
|
0.98 |
16.60% |
|
W,D + |
Neg |
CD31+; CD34-; FVIII focal + |
panCK-; AE1/3- |
10-50% |
| Epi=Epithelioid; Conv=Conventional; IHC=immunohistochemistry results; + = positive; - = negative; W = weak; M = moderate; S = strong; F = focal, D = diffuse; neg – negative; FVIII – Factor VIII; panCK = pancytokeratin; AE1/3 = cytokeratin AE1/3; 1° – primary; subQ – subcutaneous tissue; recur – recurrence; LE – lower extremity; UE – upper extremity; met – metastases; Abdo - abdomen |
|
