| Barrett’s Esophagus |
|
| Normal squamous epithelium |
flat cells without crypts or villi
bright vessels within papillae (intra papillary capillary loops |
| Non dysplastic Barrett‘s esophagus |
uniform villiform architecture
columnar cells
dark ‘goblet’ cells |
| High grade dysplasia |
villiform structures
dark, irregularly thickened epithelial borders dilated irregular vessels |
| Adenocarcinoma |
disorganized/loss of villiform structure and crypts dark columnar cells
dilated irregular vessels |
| Stomach |
|
| Normal gastric mucosa |
round regular crypts
“cobblestone“ appearence of normal glands |
| Gastric dysplasia |
irregular crypt lumen
dark, irregular,
thickened epithelium |
| Gastric adenocarcinoma |
completely disorganized epithelium
fluorescein leakage
dark irregular epithelium |
| Colon |
|
| Normal colonic mucosa |
round crypt structures
dark goblet cells
regular, narrow vessels surrounding crypts |
| Hyperplastic polyp |
crypts with slit or stellate openings (pits)
bright non-thickened, uniform epithelium
dark ‘goblet’ cells
small vessels |
| Adenoma |
irregular or villiform structures
dark, irregularly thickened epithelium
decreased goblet cells |
| Adenocarcinoma |
disorganized villiform or lack of structure
dark, irregularly thickened epithelium
dilated vessels |
| Biliary |
|
| Normal bile duct |
fine, reticular gray pattern |
| Biliary malignancy |
irregular structures interspersed with bright areas of tortuous dilated blood vessel |
