Study Organ / Targeted tissue Detection CLE Sensitivity (%) Specificity (%)
Sharmaet al. [15] Esophagus Barrett’s HGD/EAC pCLE 68.3 87.8
Pech et al. [20]) Esophagus SCC eCLE 100 87.0
Li [23] Stomach Gastric neoplasia eCLE 88.1 98.6
Kiesslich et al.[26] Colon
Polyps and random sites
Neoplasia eCLE 97.4 99.4
Hurlstone et al. [28] Colon
Polyps
Neoplasia eCLE 97.4 99.3
Meining et al.[34] Colon
Polyps
Neoplasia pCLE 93 92
Buchner et al.[34] Colon
Polyps
Neoplasia pCLE 91 76
Meining et al.[49] Bile ducts  Indeterminate
stricture
Malignancy pCLE 98 67
Konda et al.[55] Pancreas
Cysts
PCN nCLE 59 100
Table 3: Prospective In Vivo Study of CLE in Gastrointestinal Cancer