| |
Crypt architecture |
| Type 1 |
Regular luminal openings, size, and distribution of the crypts, covered by a homogeneous layer of epithelial cells, including goblet cells |
| Type 2a |
Aggregation/branching of otherwise normal crypts; normal amount of goblet cells |
| Type 2b |
Star-shaped luminal crypt openings (narrow lumen) with regular or reduced amount of goblet cells |
| Type 2c |
Star-shaped luminal crypt openings (wide lumen) with regular or reduced amount of goblet cells |
| Type 2d |
Both aggregation/fusion of regular-shaped crypts and star-shaped luminal crypt openings (combination of type 2a, 2b or 2c) |
| Type 2e |
Decreased number of crypts, irregular size of crypts, and irregular distribution of crypts, with regular or reduced amount of goblet cells |
| Type 3 |
Variable width of epithelial lining with tubular-shaped crypts and loss of goblet cells (striped dark epithelium); irregular and decreased volume of lamina propria |
| |
Vessel architecture |
| Type 1 |
Hexagonal, honeycomb appearance that presents a network of capillaries outlining the luminal openings of the crypts |
| Type 2 |
Hexagonal, honeycomb appearance with mild (or no) increase in the number of capillaries or increased amounts of normal vessels without leakage |
| Type 3 |
Dilated and distorted vessels with elevated leakage; irregular architecture with little or no orientation to adjunct tissue |
