| Lesion |
SMA |
Coll IV |
DES |
CD117 |
CD34 |
NEm |
S100 |
LCA |
CKs |
Molecular Testing |
| GlomusTumor |
+ |
+ |
- |
- |
- |
- |
- |
- |
- |
none |
| GIST |
-/+* |
-/+ |
- |
+ |
+/- |
- |
- |
- |
- |
c-KIT, PDGFRa, BRAF, SDH |
| Carcinoid |
- |
- |
- |
- |
- |
+ |
- |
- |
+ |
none |
| Paraganglioma |
- |
- |
- |
- |
+ |
+^ |
- |
- |
|
|
| Leiomyoma |
+ |
- |
+ |
- |
- |
- |
- |
- |
- |
none |
| Schwannoma |
- |
- |
- |
- |
- |
- |
+§ |
- |
- |
none |
| Granular cell tumor |
- |
- |
- |
- |
- |
- |
+§ |
- |
- |
none |
| Melanoma |
- |
- |
- |
-/+ |
- |
- |
+§ |
- |
- |
BRAF, c-KIT |
| Lymphoma |
- |
- |
- |
- |
- |
- |
- |
+ |
- |
none |
|
| Abbreviations: SMA: Smooth Muscle Actin; DES: Desmin; ChrA: Chromogranin A; Syn: Synaptophysin; CKs: Cytokeratins; CollIV: Collagen IV; *: positive in small intestine GIST; ^: Positive in Substentacular cells; §: HMB45, Melan A, tyrosinase and miTF are generally positive in melanoma, but not in other S100-positive tumors; PDGFR: Platelet-derived growth factor receptor; SDH: Succinate Dehydrogenase complex |
| Table 4: Helpful findings in differential diagnosis between Glomus Tumors and other mimicking lesions. |
