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Figure 3: A (H&E; 100x)–Shows polymorphous infiltrate of cells which are predominantly histiocytes with abundant pale eosinophilic cytoplasm admixed with numerous plasma cells and lymphocytes. B (H&E; 400x)–The histiocytes exhibit emperipolesis wherein intact lymphocytes and plasma cells are present within the cytoplasm (Arrows). C (CD68 immunostain; 400x)–The Histiocytes show diffuse strong cytoplasmic positivity whereas the plasma cells and the lymphocytes present within the cytoplasm remain unstained thereby highlighting emperipolesis better (Arrows with oval ends). D (CD1a immunostain; 400x)–There is complete absence of staining in the histiocytes indicating that they are non-Langerhan’s cell phenotype (Dotted arrows). |