| S.No. |
Age /Gender |
Reference |
Sign & Symptoms |
MRI
Finding |
Endocrine
Dysfunctions Dysfunctions |
DI |
Treatment |
Effect
of
treatment |
Out
Comes |
| 1 |
32/ F |
Dutta et.al.(present case) |
CDI, Hypopituitarism, hyperprolactinemia, normal vision |
Suprasellar mass of size 2.8×2.5×1.9 cm, T1-hypointense, T2/ flair-mildly hyperintense, homogenous contrast enhancement |
TSH, ACTH, Gonadotropin, GH, ADH deficiency |
Y |
Surgrical debulking followed by tapering dose of oral prednisolone |
Good response, mass remarkably decreased in size |
Surviving at 1 year of follow up, hypopituitarism persisted |
| 2 |
44/F |
Kutlubay et al.2014 |
CDI, Xanthelasma like skin lesion, lymph adenopathy, |
Not known |
Not known |
Y |
Systemic methyl prednisolone |
Cutaneous disease under control |
Not known |
| 3 |
27 /M |
Wang et al.2011 |
CDI,vision loss, hypopituitarism |
Sellar-supra sellar mass with anterior cranial extension, brightly enhancing on contrast |
|
Y |
Sub frontal –sphenoid surgery with gross total resection |
Massive recurrence, CDI recurred after 3.7 years, received 50 Gy fractionated RT and intermittent prednisolone |
Disease free at 5 years of follow up, hypopituitarism persisted |
| 4 |
10/F |
Wang et al. 2011 |
CDI, Hypopituitarism, normal vision, no palpable lymphadenopathy |
Sellar mass |
TSH, GH, ACTH deficiency |
Y |
Transphenoidal resection followed by 20 Gy fractionated RT |
Multiple intracranial recurrences |
Prednisolone 5 mg twice daily for 5 years, CDI improved, no recurrence, hypopituitarism persisted |
| 5 |
63/F |
Rotondo et al. 2010 |
Ataxia, diarrhoea, weight loss, abdominal pain |
Only documented dural thickening, GIT infiltration |
Normal cortisol and TSH |
N |
NA |
Death due to sepsis,
Autopsy-
Neurohypophysis involvement by RD, Pituitary gland showed only lactotroph hyperplasia |
Death |
| 6 |
43/M |
Wan et al.2008 |
Vision loss left eye, bitemporal hemianopia, headache, no lymphadenopathy |
Not mentioned |
Suprasellar solid mass 3×3×2.5 cm, encasing optic chiasma, isointense on T1 and T2, heterogenous contrast enhancement, pre-operative diagnosis-meningioma, |
N |
Transphenoidal surgery-right posterior clinoid mass |
Vision improved at 3 months of follow up |
Repeated MRI did not revealed recurrence |
| 6 |
15/F |
Woodcok et al.1999 |
Amenorrhea initially, headache, blurred vision, mild papilledema |
Enlargement of pituitary infundibulum with extension of soft tissue into the suprasellar cistren |
Hypothyrodism |
N |
Mild interval increase in size |
Biopsy;steroids |
9 months alive |
| 7 |
45/F |
Kelly et al.1999 |
Fever, Headaches, collapse, diplopia, hypernatremia, polyuria, and thirst |
Suprasellar lesion sized 2 cm in diameter, arising from the posterior pituitary. |
Hypopituitrarism with low cortisol, thyroxine and gonadotrophins |
Y |
Diminished in size |
Surgery; radiation;
DDAPV, Chemotherapy;
prednisolone |
3 years alive |
| 8 |
22/M |
Ng. H.1995 |
Polyuria and polydipsia, obese, lacked secondary sexual characteristics and libido |
Posterior pituitary 1.2 cm in diameter, extending from the tuber cinerium to the posterior portion of the pituitary fossa |
Mild hyperprolactinemia, depressed testosterone, subnormal GH and cortisol |
Y |
NA |
Biopsy;
DDAPV |
NA |
