Figure 1: Pathologic findings: The nodal architecture is totally effaced (A) with scattering large cells in a background of atypical lymphocytes (B). The large cells resemble typical Reed-Sternberg (C), lacunar (D) and mummified (E) cells. The background cells are monotonous in population and atypical in morphology (C-E). Immunohistochemically, the background cells are positive for CD3 (F), CD4 (G), but negative for CD8 (H) and CD5 (I). The large cells are negative for LCA (J, arrow) but positive for CD20 (K), CD79a (L), CD30 (M) and EBER in situ hybridization (N). CD30 staining shows membranous and dot-like positivity (M, arrow).