| Cell Type |
Receptor |
Functions |
| |
|
Chemotaxis |
Differentiation |
Effector Responses |
References |
| Innate immune cells |
| Dendritic cells |
S1PR1 |
↑/↔ |
↑ |
↑ |
[13,99,100] |
| |
S1PR2 |
ND |
ND |
ND |
[13] |
| |
S1PR3 |
↑ |
↑ |
↑ |
[14,101] |
| |
S1PR4 |
ND |
ND |
ND |
[13] |
| |
S1PR5 |
ND |
ND |
ND |
[13] |
| Eosinophils |
S1PR1 |
↑ |
ND |
ND |
[102] |
| |
S1PR2 |
ND |
ND |
ND |
[102] |
| |
S1PR3 |
ND |
ND |
ND |
[102] |
| Macrophages |
S1PR1 |
ND |
ND |
↑ |
[103,104] |
| |
S1PR2 |
↑ |
ND |
↑ |
[104] |
| Mast cells |
S1PR1 |
↑ |
ND |
ND |
[15] |
| |
S1PR2 |
↓ |
ND |
↑ |
[15,105] |
| NK cells |
S1PR5 |
↑ |
ND |
ND |
[64,106,107] |
| Neutrophils |
S1PR1 |
↑ |
ND |
ND |
[108,109] |
| Adaptive immune cells |
| T cells |
S1PR1 |
↑ |
↑ |
↑/↓ |
[76,110] |
| |
S1PR4 |
↑/↔ |
↓ |
↓ |
[111,112] |
| B cells |
S1PR1 |
↑ |
ND |
ND |
[113] |
| |
S1PR3 |
ND |
ND |
ND |
[113] |
| NKT cells |
S1PR1 |
↑ |
ND |
ND |
[107] |
| |
S1PR2 |
ND |
ND |
ND |
[107] |
| |
S1PR4 |
ND |
ND |
ND |
[107] |
|
