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Advantages |
Disadvantages |
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Zebrafish |
1.Comparison to the human reference genome shows that approximately70% of human genes have at least one obvious zebrafishorthologue |
Poor water soluble drugs and compounds cannot be well administered by zerbrafish； |
| 2. Zebrafish has abundant and quick reproductionability，short experimental cycle and cost less for high-throughput screening of candidate genes and small molecular compounds |
2. Behavior phenotypes are less sophisticated than mammalians; |
| 3. Zebrafish’s nervous structure remains the typical complexity of vertebrate systems but relatively simple enough to precisely analyses the pathophysiologic mechanism conservedduringevolution |
3. Some structures in nervous system of mammalians cannot find counterparts in zebrafishwith similar functions; |
| 4. Withover1000transgenic and mutantzebrafishstrains for researchers to choose according to different neurologic disease models，and with abroad genetic tools of zebrafish |
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Mice |
1. Mouse is the most broadly used animal tool for preclinical trials and has 90% genetic homology with human race. |
1. We cannot get visual of abnormality of mouse fetus when it happens in utero and it will be problematic to measure the exact concentration of drugs that impact mouse during embryonic period |
| 2.There are many practical genetic or molecular tools designed for researches and there are well quantified standard for mouse’s behavioral study |
2. High-throughput screening via mouse model will be time-consuming with low efficiency compared to zebrafish. |
| 3. Mouse models have already been successfully used to identify drug targets and to provide efficacious and safe dosage regimens for combination treatments in humans |
3. It is unlikely to accurately interpret how nervous circuit works in mouse brain. |
