Figure 1: Extracellular vesicles communicate between the cancer cells and tumor-supporting bystander cells, such as lymphocytes, mast cells, macrophages, granulocytes and fibroblasts. (A) In a traditional model the EVs show random distribution in the tumor microenvironment. (B) In an updated model of classical Hodgkin lymphoma (cHL) tissue, the cancer cell EVs are guided to the target cells, which might help to raise target cell selectivity and direct higher EV amounts to the selected bystander cell. (Model modified after Ratajczak et al. 2006).