Parameter HPLC TLC D1 DD1 Reported method [6]c Mean ± %RSDa 101.0 ± 1.6 100.5 ± 1.5 99.6 ± 1.0 100.9 ± 0.7 99.08 ± 1.1 Variance 2.7 2.2 1.1 0.5 1.5 n 5 5 5 5   t-test (2.02)b 0.1 0.2 1.1 1.2   F-ratio(4.39)b 1.7 1.5 1.4 3     aAverage of seven determinations bValues of theoretical t and F values at P=0.05 cReported HPLC method using C18 (4.6×10 cm 5 μm) column, mobile phase acetonitrile and water pH 3 (30:70), flow rate 1.2 mL min-1 and detection at 250 nm. The retention time of rivaroxaban was at 2.5 min. (not stability indicating method).

Table 5: Statistical comparison between the results of the proposed the proposed methods and the reported method in bulk powder.