Parameter Kobserved (min-1) t1/2 (min) t90 (min) Acid-induced degradation 0.5 M 0.0041 169.024 25.609 1 M 0.006 115.500 17.500 1.5 M 0.0081 85.556 12.963 Alkaline-induced degradation 0.7 M 0.0059 117.458 17.797 1 M 0.008 86.625 13.125 1.3 M 0.0095 72.947 11.053

Table 7: Kinetic data of pazufloxacin acidic and alkaline degradation at 70°C.