Gemifloxacin Theophylline Warfarin Omeprazole Proposed HPLC method Reported method (3) Proposed HPLC method Reported method (13) Proposed HPLC method Reported method (15) Proposed HPLC method Reported method (17) Mean 98.088 98.784 98.228 100.022 98.035 99.845 97.968 98.816 SD 2.1625 2.3580 1.0535 1.5622 2.1709 2.6743 2.4952 2.8113 n 4 4 4 4 4 4 4 4 Variance 4.6764 5.5602 1.1099 2.405 4.7128 7.1519 6.2260 7.9034 t (2.447)* 0.44   1.9   1.05   0.46   F (9.28) * 1.189   2.167   1.518   1.2694   *The values between parentheses are the corresponding theoretical values of t and F at the 95% confidence level.

Table 5: Statistical comparison between the results obtained by the proposed HPLC method and the reported methods for the analysis of gemifloxacin, theophylline, warfarin and omeprazole in human plasma.