5-FU     LV  
S. D. % CV %Accuracy   S. D. % CV % Accuracy
5-FU, API
High Conc.
(500 ng ml-1)
      LV, API
High Conc.
(1000 ng ml-1)
     
0.6438 0.1291 99.72 0.8588 0.0861 99.793
Medium Conc.
(12.5 ng ml-1)
0.2692 2.185 98.563 Medium Conc.
(25 ng ml-1)
0.3678 1.4974 98.251
Utoral, 250 mg
injection
High Conc.
(500 ng ml-1)
      Kyunrine, 15 mg injection
High Conc.
(1000 ng ml-1)
     
0.7982 0.1601 99.719 0.8728 0.0874 99.813
Medium Conc.
(12.5  ng ml-1)
0.2928 2.385 98.195 Medium Conc.
(25 ng ml-1)
0.3750 1.5393 97.444
5-FU in spiked plasma
High Conc.
(500 ng ml-1)
      LV in spiked plasma
High Conc.
(1000 ng ml-1)
     
0.9383 0.1888 99.401 1.130 0.1133 99.752
Medium Conc.
(12.5 ng ml-1)
0.0382 0.308 99.351 Medium Conc.
(25 ng ml-1)
0.3784 1.5373 98.462
Table 6: Stability data of 5-FU & LV APIs and pharmaceutical dosage forms in mobile phase and in spiked plasma.