S. No. Name of component Resolution   Idea condition Flow decrease Flow increase Temp. decrease Temp. increase Column change 1 DAB Impurity-A - - - - - - 2 DAB-2B 38.83 36.91 37.87 39.15 37.40 34.00 3 DAB Impurity-C 21.34 20.13 21.80 21.47 21.97 21.54 4 DAB Impurity-H 4.15 4.04 3.31 4.58 3.91 3.83 5 DAB Impurity-D 3.13 2.73 3.41 2.97 3.11 3.21 6 DAB Impurity-E 26.79 24.38 26.67 26.48 25.89 27.29 7 DAB Impurity-K 16.62 15.24 16.97 15.93 16.00 16.92 8 DAB Impurity-J 4.59 4.23 4.41 4.48 4.37 4.66 9 DabigatranEtexilateMesylate 4.43 4.15 4.24 4.46 4.18 4.59 10 DAB Impurity-G 18.76 17.22 17.87 19.32 18.17 19.35 S. No. Name of component Resolution   Idea condition Flow decrease Flow increase Temp. decrease Temp. increase Column change 1 DAB Impurity-A - - - - - - 2 DAB-2B 38.83 36.91 37.87 39.15 37.40 34.00 3 DAB Impurity-C 21.34 20.13 21.80 21.47 21.97 21.54 4 DAB Impurity-H 4.15 4.04 3.31 4.58 3.91 3.83 5 DAB Impurity-D 3.13 2.73 3.41 2.97 3.11 3.21 6 DAB Impurity-E 26.79 24.38 26.67 26.48 25.89 27.29 7 DAB Impurity-K 16.62 15.24 16.97 15.93 16.00 16.92 8 DAB Impurity-J 4.59 4.23 4.41 4.48 4.37 4.66 9 DabigatranEtexilateMesylate 4.43 4.15 4.24 4.46 4.18 4.59 10 DAB Impurity-G 18.76 17.22 17.87 19.32 18.17 19.35

Table 10: Robustness result in each condition