| Retaintion time ratio of impurities to Risperidone |
| Parameter altered |
Variation |
Risperidonecis N-oxide |
Bicyclorisperidone |
Z-Oxime |
Resolution between Bicyclorisperidone and Z-Oxime |
USP tailing factor of Risperidone |
| ACN Conc |
24% |
0.34 |
0.41 |
0.53 |
4.29 |
0.97 |
| 26.00% |
0.36 |
0.43 |
0.54 |
3.76 |
1.01 |
| 28% |
0.4 |
0.46 |
0.57 |
3.44 |
0.89 |
| Column Temp |
25°C |
0.37 |
0.44 |
0.55 |
3.51 |
0.93 |
| 30°C |
0.36 |
0.43 |
0.54 |
3.76 |
1.01 |
| 35°C |
0.36 |
0.43 |
0.54 |
4.12 |
0.91 |
| Flow rate (mL/min) |
32.00% |
0.41 |
0.45 |
0.54 |
3.54 |
0.97 |
| 30.00% |
0.36 |
0.43 |
0.54 |
3.76 |
1.01 |
| 28.00% |
0.32 |
0.4 |
0.52 |
3.86 |
1.13 |
|
