Residual Solvent* Trichlormethiazide Diazoxide Loratadine Tolnaftate Methanol 0.72 0.74 1.07 0.98 Ethanol 0.68 0.86 1.15 1.02 Isopropanol 0.64 0.86 1.22 0.98 1-Butanol 0.64 0.89 1.29 1.10 tert-Butanol 0.61 0.87 1.30 1.10 Methylene chloride 0.67 0.98 1.34 1.15 Chloroform 0.58 0.94 1.47 1.20 Heptane 0.78 1.13 1.75 1.25 Acetonitrile 0.78 1.02 1.13 1.07 Benzene 0.82 1.17 1.64 1.36 Toluene 0.80 1.21 1.79 1.43 Ethyl acetate 0.81 1.08 1.43 1.24 Ether 0.86 1.08 1.41 1.13 Acetone 0.89 1.06 1.29 0.99 Methyl ethyl ketone 0.87 1.13 1.42 1.26 Methyl isobutyl ketone 0.80 1.16 1.62 1.36 1,4-Dioxane 1.00 1.23 1.47 1.29 Tetrahydrofuran (THF) 1.02 1.24 1.59 1.37 Additive Concentration (mg/mL) 800 700 800 500

Table 1: Correction factors of the residual solvents in trichlormethiazide, diazoxide, loratadine, and tolnaftate spiked DMSO solutions. *Concentration levels of residual solvents are 100, 300 and 1000 ppm, and correction factors were determined by the ratios of slopes. The reported result is the average from two replicate measurements.