Residual Solvent* Additive A B C D E F Methanol 0.76 0.75 0.79 0.81 0.85 0.74 Ethanol 0.73 0.74 0.77 0.79 0.83 0.86 Isopropanol 0.71 0.71 0.76 0.77 0.80 0.86 1-Butanol 0.64 0.67 0.72 0.71 0.78 0.89 tert-Butanol 0.70 0.69 0.74 0.75 0.77 0.87 Methylene chloride 0.72 0.75 0.84 0.82 0.80 0.98 Chloroform 0.64 0.68 0.77 0.75 0.72 0.94 Heptane 0.84 0.86 0.91 0.85 0.85 1.13 Acetonitrile 0.82 0.81 0.86 0.90 0.95 1.02 Benzene 0.83 0.87 0.95 0.94 0.94 1.17 Toluene 0.80 0.84 0.94 0.91 0.92 1.21 Ethyl acetate 0.84 0.85 0.89 0.88 0.94 1.08 Acetone 0.92 0.91 0.92 0.96 1.02 1.06 Methyl ethyl ketone 0.89 0.89 0.93 0.93 1.00 1.13 Methyl isobutyl ketone 0.81 0.82 0.88 0.85 0.92 1.16 1,4-Dioxane 0.92 0.96 0.99 0.98 1.07 1.23 Tetrahydrofuran (THF) 0.96 1.00 1.03 1.00 1.08 1.24 Average 0.80 0.81 0.86 0.86 0.90 1.03

Table 2: Correction factors of the residual solvents in hydroflumethiazide (A) trichlormethiazide (B) benzthiazide (C) meticrane (D) benzenesulfonamide (E) diazoxide and (F) spiked solutions. *Concentration levels of residual solvents are 100, 300 and 1000 ppm, and correction factors were determined by the ratios of slopes. The reported result is the average from two replicate measurements.