Residual Solvent* NMP DMA DMSO BA 1-Butanol 0.63 0.86 0.71 1.31 Chloroform 0.50 0.57 0.63 1.09 Acetone 1.05 1.10 1.08 1.83 Tetrahydrofuran (THF) 1.07 1.12 1.15 1.41

Table 4: Benzenesulfonamide matrix effect on correction factors in different diluents. *Concentration levels of residual solvents are 100, 300 and 1000 ppm, and correction factors were determined by the ratios of slopes. The reported result is the average from two replicate measurements.