Figure 5: The impact of obesity on hepatocytes. This figure represents the adverse effects of adipocytes on hepatocytes. Influx of FFAs to hepatocytes result in reduced glucose uptake via impaired GLUT4 translocation, reduced glycogen synthesis and increased production of apoB-containing lipoproteins and accumulation of triglyceride. FFAs also stimulate inflammatory proteins and coagulation factors that increase the risk of vascular diseases. TGF-β1 not only participates in fibrosis, but also potentiates other cytokines in inflammation. Resistin facilitates FFAs in lipoprotein and glucose metabolism whereas Leptin, adiponectin and IL6 exert protective effects on hepatocytes.