Day of probe trial Time spent in the target quadrant (s) control Aβ Aβ+IBU-GSH 6 35 ± 1 33 ± 1 37 ± 2 12 22 ± 2 18 ± 1 34 ± 1a

Table 1: Effects of drug administration on spatial reference memory in a Morris water maze. Performance during probe trial was expressed as the mean (± SD) of time spent in the target quadrant where the platform had been during five consecutive days of training from control, Aβ, and Aβ+IBU-GSH treated groups on day 6 and on day 12. a: p <0.05 Aβ+IBU-GSH vs Aβ.