Pathologist 1
Pathologist 2   IIBD+ IIBD- Total
IIBD+ 53§ 4* 57
IIBD- 11† 13 24
Total 64 17 81
Po (observed agreement)=(53 + 13)/81 = 0.815
Pe (expected agreement)=[(64/81) × (57/81)] + [(17/81)×(24/81)]
Kappa=(Po-Pe)/(1-Pe)=0.51
IIBD: intraparenchymal isolated bile ductule.
*The detected number of IIBDs by Pathologist 1 was “1” in 2 cases and “2” in 2 cases.
†The detected number of IIBDs by Pathologist 2 was “1” in 6 cases, “2” in 4 cases, and“3” in 1 case.
§The mean numbers of IIBDs detected by Pathologist 1 and Pathologist 2 were “4.5” (range, 1-18) and “3.7” (range, 1-13), respectively.
Table 2: Interobserver variation regarding recognition of IIBD on the basis of H&E-stained histology.