Factors Category p53 expression Pvalue
    Negative (n=48) 1+ (n=17) Overexpression (n=21)  
Age (years) Mean±SD
(range)
56.3±12.4
(33~80)
59.6 ± 12.8 (44~80) 54.5±12.3
(36~75)
0.454
Nuclear grade 1,2 43 14 15  
  3 4 3 6 (29%) 0.100
ER - 9 4 15 (71%)  
  + 38 13 6 0.001
PgR - 12 10 15 (71%)  
  + 35 7 6 0.004
HER2 - 36 10 8  
  + 12 7 13(62%) 0.013
Ki-67 - 38 7 2  
  + 10 10 19 (91%) <0.0001
Surgery Bp 35 11 10 (48%)  
  Bt 12 6 10 (48%) 0.263
Adjuvant therapy None 18 4 12 (57%)  
Chemotherapy 1 3 5  
  Endocrine therapy 26 9 4  
  Chemo-endocrine therapy 2 1 0  
Subtype Luminal A-like 27 6 0 (0%)  
Luminal B-like 5 3 3(14%)  
HER2 6 3 9 (43%)  
Luminal/HER2 6 4 4 (11%)  
Triple Negative 7 2 3 (9%)  
Table 3b: p53 expression and clinicopathological factors in patients with T1a.