Factors Category Univariate analysis Multivariate analysis     Odds ratio Pvalue Odds ratio Pvalue Nuclear grade 3 vs 2.1 1.636 0.652 7.798 0.101 ER + vs - 1.832 0.295 0.085 0.100 PgR + vs - 2.234 0.121 2.049 0.572 HER2 + vs - 0.358 0.034 0.329 0.112 Ki-67 + vs - 0.296 0.007 0.532 0.271 P53 overexpression + vs - 0.155 <0.0001 0.077 0.002

Table 4: Univariate and Multivariate analysis for the surgical margin status among 160 (60%) patients with DCIS who received breastconserving surgery.