Groups Major epithelial thickness P-value Number of congested blood vessels P-value Saline/water Saline/honey 43.8 ±4.35 44.2 ±3.30 0.565 1.10 ±0.45 0.8±0.20 0.627 Saline/water MTX/water 43.8 ±4.35 19.22 ±3.56 0.000 1.10 ±0.45 5.30 ±0.22 0.000 Saline/water MTX/honey 43.8 ±4.35 41.43 ±2.99 0.119 1.10 ±0.45 1.98 ±0.80 0.327 Saline/honey MTX/water 44.2 ±3.30 19.22 ±3.56 0.000 0.8±0.20 5.30 ±0.22 0.000 Saline/honey MTX/honey 44.2 ±3.30 41.43 ±2.99 0.129 0.8±0.20 1.98 ±0.80 0.193 MTX/water MTX/honey 19.22 ±3.56 41.43 ±2.99 0.009 5.30 ±0.22 1.98 ±0.80 0.000

Table 1: Comparison between groups in the means and standard deviations of the histopathological parameters used in the study in rat’s tongue mucosa following water or honey administration in female Albino rats post saline or methotrexate injection.