Groups Ki-67 P-value Bcl-2 P-value Saline/water 16.33± 0.24 0.443 9.12±0.50 0.195 Saline/honey 17.14±0.22 9.98 ± 0.61 Saline/water 16.33± 0.24 0 9.12±0.50 0 MTX/water 1.12 ± 0.10 0.02 Saline/water 16.33± 0.24 0 9.12±0.50 0.007 MTX/honey 2.16 ± 0.35 4.16 ± 0.22 Saline/honey 17.14±0.22 0 9.98 ± 0.61 0 MTX/water 1.12 ± 0.10 0.01±0.02 Saline/honey 17.14±0.22 0 9.98 ± 0.61 0.005 MTX/honey 2.16 ± 0.35 4.16 ± 0.22 MTX/water 1.12 ± 0.10 0.022 0.01±0.02 0.003 MTX/honey 2.16 ± 0.35 4.16 ± 0.22

Table 2: Comparison between groups in the means and standard deviations of the immunohistochemical results in rat’s tongue mucosa following water or honey administration in female Albino rats post saline or methotrexate injection.