Non-rheumatic AVs
with HO(n=8)
Non-rheumatic AVs without HO (n=36) P-value
Age (y), range (mean) 67-84 (76.1) 52-88 (73.9) 0.558*
Gender (male/female) 4/4 20/16 0.915†
Moderate to severe calcification 8 17 0.007‡
Moderate to severe fibrous thickening 7 9 0.002‡
ThNC-Vs only 8 15 0.004‡
Foamy cell aggregation 3 8 0.391†
Lymphoplasmacytic infiltration 6 9 0.013‡
Metaplastic cartilage (fibrous and/or hyaline cartilage) 3 2 0.039‡
AVs: aortic valves; HO: heterotopic ossification; ThNC-Vs: thin capillary vessel-like neovessels; ThKA-Vs: thick arteriole-like neovessels.
*Unpaired t-test.
†Chi-square test.
‡Fisher’s exact test.
Table 2: Clinicopathological comparison of 44 non-rheumatic dysfunctional aortic valves with and without heterotopic ossification.