| TGF-Β signaling components are known to regulate: |
TGF-Β signaling components may regulate: |
| Insulin gene transcription |
Β-cell response to hyperglycemia: |
| Glucose-stimulated insulin secretion |
Adaptive dedifferentiation
|
| Compensatory Β-cell proliferation accompanied by transient dedifferentiation to a PP+ state |
NF-κB-mediated Β-cellapoptosis in the context ofislet inflammation
|
| Mature Β-cell transcriptional program (through MafA expression) |
|
The left-hand column summarizes established findings; the right-hand
column offers hypotheses for further studies. |
|
