Plate 1: A: Control group renal cortex showing renal corpuscles. Glomeruli (G) formed of capillary tufts are surrounded by Bowman’s capsules (arrow). Note acidophilia of proximal (P) and distal (D) convoluted tubules cells with vesicular nuclei. B, C: Triclosan treated group renal cortex showing glomerulus (G) with increased cellularity with obliteration of the Bowman’s space (arrow). Some tubules show desquamation of tubular epithelial cells (curved arrow) while others show marked cellular disorganization (double arrows). Intracellular vacuoles (arrowhead) and casts (c) are observed in some tubules. Many inflammatory cells (I) are noticed. Other glomerulus (G) appears destructed with dark stained nuclei (crossed arrow) and congested capillaries (white arrow). Dilated tubules (T) with flattened epithelium are detected. Congested blood vessels (C) are also seen. D: Triclosan-ellagic acid group renal cortex showing glomeruli (G) with their capillary tufts, surrounded by Bowman’s capsules (arrow). Proximal (P) and distal convoluted tubules cells (D) haveacidophilic cytoplasm and vesicular nuclei Few distorted tubules (double arrow) could be seen. (scale bar 25 μm, H& E stain).