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Plate 4: A, B: Control group showing podocytes (P) and processes. Observe irregular euchromatic nucleus of podocyte (n) and the fenestrated endothelium of the capillary (double arrows). Primary process (arrow), interdigitating secondary process (arrow head) is noticed. GBM (curved arrow) is formed of a central electron dense lamina densa and lamina rarae on either side. C, D: Triclosan treated group showing podocytes with electron dense nuclei (n) with effacement of the foot processes (arrow head) and focal thickening of the glomerular basement membranes (curved arrow). E, F: Triclosan-ellagic acid treated group showing podocytes (P) with irregular electron lucent nuclei (n). Their primary processes (arrow), secondary processes (arrow heads) and uniform thickness of GBM (curved arrow) are also detected. Fenestrated blood capillary (double arrows) could also noticed. (scale bar, A, C, E: 2 μm & B, D, F: 200 nm). |