Feature ChK2-negative (18) ChK2-positive (40) p-value
Gender        
Male     
Female		 12
6		 20
20		 0.268
Age
>65 years
<65 years		 4
14		 15
25		 0.367
Histology
Adenocarcinoma
Mucinous carcinoma		 17
1		 33
7		 0.413
Stage T
T2
T3
T4		 3
10
5		 2
28
10		 0.302
Stage N
N0
N1
N2		 1
8
9		 15
11
14		 0.042
Clinical Stage (EC)
CSII
CSIII
CSIV		 0
7
11		 8
7
25		 0.051
Obstructed/perforated acute abdomen (OPAA)
Present
Absent		 6
12		 10
30		 0.538
Metastasis
Synchronous
Metachronous 		11
7		 25
15		 1.0
Lymph node involvement
Present
Absent 		17
1		 25
15		 0.012
Death
Yes
No 		3
15		 18
22		 0.044
Recurrence
Yes
No 		13
5		 36
4		 0.119
Liver metastasis
Present
Absent 		16
2		 31
9		 0.474
Lung metastasis
Present
Absent 		10
8		 17
23		 0.404
Degree of tumor cell differentiation
Grade I+II
Grade III		 16
2		 37
3		 0.641
ECOG
ECOG 0+1
ECOG 2		 17
1		 37
3		 1.0
Table 2: Analysis of the association between the clinicopathological characteristics and the CHK2 immunohistochemical expression status (positive or negative) in colon neoplasm. Caption: stage T (TNM)—T2: tumor invades muscularis propria, T3: tumor invades through the muscularis propria and enters pericolorectal tissues, T4: tumor penetrates the visceral peritoneum surface or directly invades it or adheres to other organs or structures; stage N (TNM), N0: No regional lymph node metastasis, N1: Metastasis in 1 to 3 regional lymph nodes, N2: Metastasis in 4 or more regional lymph nodes; ECOG: Eastern Cooperative Oncology Group, degree of cell differentiation: Grade I: well differentiated, grade II: moderately differentiated, and grade III: little differentiated