Figure 1: Comparison of histologic findings in 2001 and 2013 lymph nodes. Histologic sections of the lymph node from 2001 show well preserved overall architecture (A); The follicles show intact mantle zones and lack tangible body macrophages (B); A predominance of small cleaved cells are present within follicles(C); Histologic sections of the 2013 lymph node shows variably sized follicles (D); The follicles show intact mantle zones (E); The interfollicular areas are rich in polymorphous small and occasional large lymphoid cells and histiocytes (F); Some follicles show enlargement and lack of mantle zones (G); These follicles also show increased numbers of large cells consistent with grade 3A morphology (H); A selected interfollicular area shows increased and atypical large cells, some resembling Hodgkin cells (I); Immunohistologic staining for CD20 highlights follicles as well as an interfollicular component (J); CD3 shows dense staining in the interfollicular/paracortical areas (K); CD21 highlights intact and expanded follicular dendritic cell meshworks (L).