Gene Bone tissue of P value Treated lesion Untreated area Acp5 0.12 ± 0.024 0.116 ± 0.015 n.s. Alpl 0.096 ± 0.017 0.084 ± 0.009 n.s. Bglap 0.87 ± 0.13 1.85 ± 0.25 P=0.002 Col1a1 3.04 ± 0.56 4.15 ± 0.42 P=0.041 IGF1 0.46 ± 0.09 0.39 ± 0.05 n.s. IGF2 1.17 ± 0.18 1.04 ± 0.17 n.s. Phex 0.073 ± 0.022 0.031 ± 0.002 n.s. Runx2 0.002 ± 0.0002 0.0027 ± 0.0003 P=0.015 VEGFA 0.093 ± 0.015 0.095 ± 0.015 n.s.

Table 1: Gene specific transcription levels in rat bone tissue samples. The mRNA levels are given in relation to those of 18S rRNA. Means ± S.E.M. are given in all cases for n=10 samples. P values indicate statistical significant differences between bone tissue of treated lesions and untreated initial bone tissue, Mann Whitney U rank sum test. n.s.=not significant.