Figure 1: Sections from Rat liver at the region of Central vein stained by H&E showing (A) Control group (G1) with normal central vein (CV), hepatocytes cords (black arrows) separated by thin walled blood sinusoids (white arrows). (B) G2 (8 mg) showing numerous apoptotic hepatocytes (thin black arrows) prominent sinusoidal Von kupffer cells (white arrows). (C) G3 (8 mg+Mof) Normal hepatocytes (arrows) prominent Von kupffer cells are still present but less compared to G2 (white arrows). (D) G8 (150 mg) showing in the same hepatic lobule focal areas of degenerated hepatocytes with loss of lobular architecture (white star), aggregation of apoptoic cells (black arrows) and many congested blood sinusoids (arrowheads). (E) another sample showing congestion of central vein with nearby hepatocytes (black star) containing many lipid droplets (microvesicular steatosis). (F) G9 (150 mg+Mof) Hepatocytes looked almost normal few cells showed signs of apoptosis (black arrows), no steatosis (black star).