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Figure 3: Photographs of TEM sections showing: (A) Control liver parenchyma: Hepatocytes (H) with rounded, euchromatic nucleus (N) separated by blood sinusoids (S). (B) The cells showed numerous normal shaped mitochondria of various sizes (white arrows) as well as clusters of (rER) tubules (stars). (C) G2 (8 mg): dilated blood sinusoids (S). (D) enlarged pleomorphic mitochondria (white arrows) and dilated rER tubules (black arrows) the nucleus (N) showed slight increase in peripheral chromatin and elaborating microvilli project in the space of Disse (stars). (E) G3 (8 mg+Mof) showing hepatocyte with almost normal cell organelles, rER (black arrows) and mitochondria (white arrows) .The nucleus (N) showed patches of heterochromatin. (F) G8 (150 mg) : showing focal areas of degenerated cytoplasmic organelles leaving vacuoles. They contain fine granular or cellular debris and myelin figures (black arrows). There are numerous pleomorphic enlarged or deformed mitochondria (white arrows). (G) G9 (150 mg+Mof) almost normal hepatocytes structure with normally appeared mitochondria and rER tubules still few lipid droplets were detected (arrowheads). the nucleus ( N) showed slight condensation of peripheral chromatin. |