Figure 8: Electron micrograph of two year rats’ skin showing: (a) well developed collagen fibres (C) and elastic fibres (E). The nucleus (N) of the basal cell fills the major part of the cell and the cells are attached to their neighbors by desmosomes (thick arrow) and to the well-developed basal lamina (arrowheads) by hemidesmosomes (*). Note the presence of bundles of tonofilaments (t) in the stratum basale cells (6000X). (b) well developed collagen fibres (C), fibroblast (F) with its process and the stratum basale cells (SB) which are attached to their neighbors by desmosomes (thick arrows) and to the well-developed basal lamina (arrowheads) by hemidesmosomes (thin arrow). Note intercellular spaces (*) in-between the stratum basale cells (4000X). (c) A melanocyte (MN) with its nucleus (N) and its dendritic processes (P) which extend between the basal cells. Note stratum basale cells (B) with their hemidesmosomes (H). Tonofilaments (t) were seen in stratum basale and stratum spinosum cells. Note the well-developed basal lamina (arrowheads) and the nucleus of a stratum spinosum cell (S) (6000X). (d) Cells of stratum spinosum (S) and stratum granulosum (G) with their keratohyalin granules (K) (2500X). (e) The stratum corneum cells (C) filled with electron-dense materials (arrowheads) (3000X).