Figure 1: Nuclei of benign thyroid cells from two nodules (A and B) stained by the AgNOR method (100x) The mean AgNOR counts were 3.11 and 1.06, mean AgNOR areas 3.98 μm2 and 1.96 μm2, and mean nuclear areas 49.4 μm2 and 18.1 μm2 in A and B, respectively. The volume of nodule A increased by 118% while the volume of nodule B decreased by 28% over 10 years.