Study Country No. of nodules Mean follow-up (months) Criteria of increase Increased Decreased No change
% of nodules
Papini et al. [18] Italy 41 60  volume ≥ 11.7% 56 22 22
Rago et al. java script : new show content ('active', 'references'); [15] Italy 27 36 volume ≥30% 11·1 - -
Quadbeck et al.[16] Germany 139 59 volume ≥30% 61·2 23 15·8
Alexander et al. [18] USA 330 20 volume ≥15% 39 - -
Erdogan et al. [7] Turkey 531 39  volume ≥ 30% 24·1 20·7 55·2
Present study Hungary 106 143  volume ≥ 30% 51.2 16.0 32.8
Table 6: Previous studies on the natural course of benign thyroid nodules.