No of samples/group p16 status HPV DNA status from FFPE material HPV DNA+ status using material from glass slides CUP 18 + + 16/18 CUP 27 - - 0/23 * CUP 2 - + 0/2 CUP 3 + - 0/3

* 4 samples lacked b-globin

Table 2: HPV status and p16 overexpression in tumor metastasis and p16 stained glass slides derived from 50 patients with cancer of unknown primary (CUP) in the head and neck region.