Factors Referral Status t- test p-value 95% CI Min. Max.
Yes
(n= 96)
No
(n= 15)
Mean SD Mean SD
Promotersa                  
Physician benefits summary score 10.74 3.07 11.33 2.87 0.697 0.487 -1.08 – 2.24 4.00 20.00
Trial benefits summary score 6.72 2.35 7.20 2.43 0.741 0.460 -0.81 – 1.78 3.00 15.00
Patient psychosocial benefits summary score 4.27 1.16 4.87 0.92 1.903 0.060 -0.03 – 1.22 2.00 7.00
Patients are followed closely 2.42 0.87 2.47 0.64 0.214 0.831 -0.41 – 0.51 1.00 5.00
Comfortable explaining trial to patients 2.35 0.67 2.33 0.82 -0.109 0.913 -0.40 – 0.36 1.00 4.00
Logistical Barriersa                  
Clinical trial process burden summary score 16.14 4.73 12.00 3.34 -3.26 0.001 -6.65 – -1.62 6.00 30.00
Coordination/Involvement with clinical trial site summary score 8.15 2.87 7.07 1.75 -2.00 0.055 -2.18 – 0.26 3.00 15.00
Personal Barriersa                  
Physician attitudes items summary score 24.58 5.02 22.27 4.27 -1.693 0.093 -5.03 – 0.40 7.00 35.00
Lack of personal benefits items  summary score 11.40 2.54 9.20 2.60 -3.105 0.002 -3.60 – -0.79   3.00 15.00
Lack of awareness 2.45 0.99 2.33 0.62 -0.61 0.549 -0.50 – 0.27 1.00 5.00
Trial Protocol-Related Barriersa                  
Protocol complexity items summary score 14.60 3.52 12.27 3.04 -1.434 0.017 -4.24 – -0.43 5.00 25.00
Trial treatment items summary score 9.09 2.48 9.60 2.56 0.732 0.466 -0.86 – 1.88   3.00 15.00
aResponse options: Strongly agree = 1 to strongly disagree = 5, with higher mean scores indicating greater disagreement
Table 3: Means Comparison of Summary Scores of Promoters and Logistical, Personal and Trial-Related Barriers by Referral Status.