PATIENT ID AGE RURAL/ URBAN CLNICAL TUMOR STAGE EXON CODON NUMBER NUCLEOTIDE NUMBER MUTATION cDNA SEQUENCE BASE CHANGE AMINO ACID CHANGE MUTATIONEFFECT 15N 45/M R GRADE III 5 169 13185 506delT ATG>A_G NS (Met>Arg) FS 15T 5 147 13118 439G>T GTT>TTT Val>Phe MS 5 179 13214 535 C>G CAT>GAT His>Asp MS 15L 5 170 13189 510InsT ACG>ACTG NS (Thr>Thr) FS 5 173 13197 518delT GTG>G_G NS (Val>Gly) FS 6 213 13397 636C>G CGA>GGA Arg>Gly MS (at CpG)

Table 2: Clinico-epidemiological details and nature of TP53 mutations in germline gastric adenocarcinoma patients from Kashmir valley.