Allele

 

Genotype

                                     PATIENTS

                              CONTROLS   

DI± S.E.M. (n)

DF± S.E.M. (n)

Mean  DNA migration length ± S.E.M. (n)

DI± S.E.M. (n)

DF± S.E.M. (n)

$Mean  DNA migration length ± S.E.M. (n)
HLA-C region

 

 22222* (G→A)

GG

28.38***±1.79 (12)

55.23***±3.28 (12)

37.51***±1.56 (12)

4.88±1.28  (9)

11.77±2.59 (9)

9.38±1.94 (9)

GA

28.41***±1.94 (16)

55.29***±3.62 (16)

33.78***±2.60 (16)

6.75±2.56  (4)

13.50±5.12 (4)

12..29±4.36 (4)

AA

33.42*±2.12  (7)

62.85*±3.17  (7)

33.41*±3.49  (7)

6.00±1.00  (2)

12.00±2.00 (2)

9.07±0.68 (2)
22333* (A→G)

AA

28.25**±1.95  (12)

54.83***±3.54  (12)

36.92***±1.58  (12)

10.66±5.10  (9)

11.33±2.78 (9)

8.79±2.17 (9)

AG

28.31***±2.06 (16)

55.12***±3.85 (16)

33.86***±2.77 (16)

6.75±2.56  (4)

13.50±5.12 (4)

12.29±4.36 (4)

GG

33.57*±1.70 (7)

62.85*±3.17 (7)

33.41*±3.49  (7)

6.00±1.00 (2)

12.00±2.00 (2)

9.07±0.68 (2)
24118* (T→C)

TT

28.90***±2.01 (11)

56.18***±3.59 (11)

36.76***±1.72 (11)

9.00±3.60  (13)

11.07±2.28 (13)

8.69±1.77 (13)

TC

27.72±1.87  (18)

53.88±3.53  (18)

34.02±2.47 (18)

9.00±0.00 (1)

18.00±0.00 (1)

17.56±0.00 (1)

CC

34.83±1.88  (6)

65.33±2.34 (6)

33.66±4.12  (6)

9.00±0.00  (1)

18.00±0.00 (1)

15.79±0.00 (1)
CCHCR1 gene 386* (C→T)

CC

26.09***ª±2.02 (11)

50.36***ª±3.51(11)

32.83***ª±2.38 (11)

9.28±3.32 (14)

9.28±3.32(14)

9.86±1.82(14)

CT

29.40±1.59 (21)

57.40±3.06(21)

36.31±2.11 (21)

5.00±0.00 (1)

10.00±0.00(1)

8.39±0.00(1)

TT

37.00 ª ±2.64(3)

66.66 ª ±1.33(3)

36.37 ª ±5.66(3)

-

-

-
404* (C→T)

CC

25.66*** b ±1.84  (9)

49.33*** b ±2.84 (9)

31.32***±2.60 ( 9)

9.28±3.32  (14)

12.14±2.21 (14)

9.86±1.82 (14)

CT

30.30 b ±1.70  (20)

59.20 b ±3.21 (20)

35.07±2.05  (20)

5.00±0.00 (1)

10.00±0.00 (1)

8.39±0.00 (1)

TT

31.50±3.41  (6)

58.66±5.35 (6)

39.24±3.85  (6)

-

-

-
1364* (T→C)

TT

28.01***±4.27 (10)

56.20***±5.92 (10)

38.14***±3.61 (10)

6.40±1.39 (10)

12.80±2.78 (10)

10.83±2.22(10)

TC

30.31***±1.47(17)

59.12***±2.57 (17)

34.64***±1.93 (17)

5.25±1.93 (4)

10.50±3.86(4)

7.63±3.25(4)

CC

25.60±2.37 (8)

10.00±0.00 ( 8)

30.00±4.23 (8)

50.00±0.00 (1)

10.00±0.00(1)

7.55±0.00(1)
***Very highly significant (p≤0.001), ** highly significant (p≤0.01), *significant (p≤0.05) when compared to parallel control groups (Mann Whitney -U-test) ***ª Very highly significant when compared to parallel control group (p<0.001) and significant (p<0.05) within patient group (386*(C→T) Homozygous wild type patient group vs Homozygous mutant patient group; p≤0.05) (Mann Whitney -U-test) *** b Very highly significant when compared to parallel control group (p<0.001) and significant(p<0.05) within patient group (404*(C→T) Homozygous wild type patient group vs Heterozygous mutant patient group; p≤0.05) (Mann Whitney -U-test) DI-Damage index; DF- Damage frequency; $-Calculated as an average of individual DNA migration lengths in that group
Table 1: HLA-C and CCHCR1 genotypes and DNA damage in Psoriasis patients and controls.