Figure 1: FISH analysis of interphase nuclei with MN using LSI probe (orange) for c-MYC gene. Photomicrographs of loss c-MYC gene by MNHeps detected in samples from cirrhotic and HCC nodules of HCV infected patients. a- MN with one signal; b- binucleated hepatocytes with one signal in the nucleus, and another in MN; c- hepatocyte with ten signals in the nuclei and one in MN; d- hepatocyte showing a large MN without signal and nucleus having four signals; e- hepatocyte with two MN, with and without signal; f- hepatocyte with two MN, each one with one signal, and also in the nucleus. The arrows indicate: (→) MN without signal, and (═>) MN with +c-MYC signal.