Figure 2: IC50 evaluation and apoptosis and cell cycle analyses. (A) Dose-response curves revealed IC50 is 70μM for adherent cells and it is > 150 μM for chondrospheres; (B) chondrospheres showed profound chemoresistance to cisplatin compared with the adherent cells; (C) Cisplatin treatment induced S-phase block in adherent cells and an increase in G0G1-phase chondrosphere cells only at high concentrations.