| Dosage(μg/kg) |
Sample |
OD value |
|
Number of antibody-positive animals |
| Week 4 |
Week 8 |
Week 4 |
Week 8 |
| 0 |
Serum |
0.068 ± 0.006 |
0.068 ± 0.008 |
0/5 |
0/5 |
| 20 |
Serum |
0.064 ± 0.004 |
0.073 ± 0.009 |
0/5 |
0/5 |
| 100 |
Serum |
0.064 ± 0.007 |
0.073 ± 0.003 |
0/5 |
0/5 |
| 500 |
Serum |
0.068 ± 0.019 |
0.072 ± 0.013 |
0/5 |
0/5 |
| — |
Positive antibody (anti-G-CSF) |
1.109 ± 0.090 |
|
— |
— |
aAdult Sprague-Dawley rats were injected daily with G-CSFa subcutaneously at the dose of 0 (vehicle control), 20, 100, or 500 μg/kg, for up to 4 weeks. Peripheral blood
serum was obtained for ELISA analysis either at the end of the 4-week treatment period (week 4) or after a further 4-week recovery period (week 8) |
