| |
Control group (n= 207) n (%) |
G1 (n= 23) n (%) |
G2 (n= 89) n (%) |
G3 (n= 16) n (%) |
|
ptotal |
p |
OR |
95%CI |
| rs3136176 |
| Genotype |
| [AA] |
116 (56.0) |
13 (56.5) |
47 (52.8) |
7 (43.8) |
|
ns1
ns2
0.013
ns4
ns5
ns6 |
referent |
| [AT] |
81 (39.1) |
7 (30.4) |
34 (38.2) |
5 (31.2) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
0.57
0.71
0.77
0.57
1.00
0.77 |
1.34
1.33
0.99
0.76
0.99
1.00 |
0.49 – 3.72
0.31 – 5.77
0.29 – 3.38
0.29 – 1.98
0.58 – 1.67
0.31 – 3.26 |
| [TT] |
10 (4.8) |
3 (13.1) |
8 (9.0) |
4 (25.0) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
1.00
0.56
0.20
0.35
0.18
0.01* |
0.74
2.48
3.36
2.65
1.96
6.57 |
0.17 – 3.18
0.43 – 14.34
0.80 – 14.16
0.65 – 10.89
0.73 – 5.27
1.64 – 26.33 |
| Allele |
| [A] |
313 (75.6) |
33 (71.7) |
128 (71.9) |
19 (59.4) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
|
1.00
0.25
0.15
0.56
0.34
0.04 |
1.01
0.58
0.57
0.82
0.83
0.47 |
0.49 – 2.07
0.22 – 1.49
0.26 – 1.24
0.42 – 1.62
0.56 – 1.23
0.23 – 0.99 |
| [T] |
101 (24.4) |
13 (28.3) |
50 (28.1) |
13 (40.6) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
1.00
0.25
0.15
0.56
0.34
0.04 |
0.99
1.74
1.75
1.22
1.21
2.12 |
0.48 – 2.04
0.67 – 4.51
0.81 – 3.81
0.62 – 2.41
0.81 – 1.80
1.01 – 4.45 |
| Dominant model |
| [AA]+[AT]
vs.
[TT] |
197 (95.2) |
20 (84.9) |
81 (91.0) |
12 (75.0) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
|
0.85*
0.59*
0.15*
0.25*
0.17
0.008* |
1.52
2.22
0.30
0.34
0.51
0.15 |
0.37 – 6.25
0.42 – 11.68
0.08 – 1.14
0.09 – 1.33
0.20 – 1.35
0.04 – 0.56 |
| 10 (4.8) |
3 (13.1) |
8 (9.0) |
4 (25.0) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
0.85*
0.59*
0.15*
0.25*
0.17
0.008* |
0.66
0.45
3.38
2.96
1.95
6.57 |
0.16 – 2.71
0.09 – 2.37
0.88 – 12.95
0.75 – 11.63
0.74 – 5.11
1.79 – 24.01 |
| Recessive model |
| [TT]+[AT]
vs.
[AA] |
91 (44.0) |
10 (43.5) |
42 (47.2) |
9 (56.2) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
|
0.75
0.43
0.50
1.00
0.61
0.34 |
1.16
1.67
1.44
0.98
1.14
1.64 |
0.46 – 2.93
0.46 – 6.05
0.49 – 4.20
0.41 – 2.34
0.69 – 1.88
0.59 – 4.57 |
| 116 (56.0) |
13 (56.5) |
47 (52.8) |
7 (43.8) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
0.75
0.43
0.50
1.00
0.61
0.34 |
0.86
0.60
0.70
1.02
0.88
0.61 |
0.34 – 2.17
0.17 – 2.17
0.24 – 2.03
0.43 – 2.43
0.53 – 1.45
0.22 – 1.70 |
| rs1799798 |
| Genotype |
| [GG] |
162 (78.3) |
14 (60.9) |
68 (76.4) |
11 (68.8) |
|
0.067
ns8
ns9
ns10
ns11
ns12 |
referent |
| [GA] |
42 (20.3) |
7 (30.4) |
19 (21.3) |
5 (31.2) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
0.27
0.83*
0.62*
0.18
0.81
0.49* |
0.56
1.10
1.63
1.93
1.08
1.75 |
0.20 – 1.58
0.27 – 4.43
0.50 – 5.26
0.73 – 5.08
0.59 – 1.99
0.58 – 5.32 |
| [AA] |
3 (1.4) |
2 (8.7) |
2 (2.2) |
0 (0.0) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
0.32*
0.64*
0.63*
0.09*
1.00*
0.45* |
0.21
–
–
7.71
1.59
– |
0.03 – 1.59
–
–
1.19 – 50.09
0.26 – 9.72
– |
| Allele |
| [G] |
366 (88.4) |
35 (76.1) |
155 (90.1) |
27 (84.4) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
|
0.06
0.54*
1.00*
0.02
0.65
0.69* |
2.12
1.70
0.80
0.42
1.13
0.71 |
0.95 – 4.75
0.53 – 5.47
0.28 – 2.29
0.20 – 0.88
0.67 – 1.93
0.26 – 1.93 |
| [A] |
48 (11.6) |
11 (23.9) |
23 (9.9) |
5 (15.6) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
0.06
0.54*
1.00*
0.02
0.65
0.69* |
0.47
0.59
1.25
2.40
0.88
1.41 |
0.21 – 1.06
0.18 – 1.90
0.44 – 3.57
1.14 – 5.03
0.52 – 1.50
0.52 – 3.84 |
| Dominant model |
| [GG] + [GA]
vs.
[AA] |
204 (98.6) |
21 (91.3) |
87 (97.8) |
16 (100.0) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
|
0.39*
0.22*
0.15*
0.13*
1.00*
0.52* |
4.14
–
–
0.15
0.64
– |
0.55 – 31.14
–
–
0.02 – 0.98
0.11 – 3.90
– |
| 3 (1.4) |
2 (8.7) |
2 (2.2) |
0 (0.0) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
0.39*
0.22*
0.15*
0.13*
1.00*
0.52* |
0.24
–
–
6.48
1.56
– |
0.03 – 1.81
–
–
1.02 – 40.97
0.26 – 9.52
– |
| Recessive model |
| [AA] + [GA]
vs.
[GG] |
45 (21.7) |
9 (39.1) |
21 (23.6) |
5 (31.2) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
|
0.13
0.87*
0.73*
0.06
0.72
0.57 |
0.48
0.71
1.47
2.31
1.11
1.64 |
0.18 – 1.27
0.18 – 2.72
0.46 – 4.72
0.94 – 5.69
0.62 – 2.01
0.54 – 4.95 |
| 162 (78.3) |
14 (60.9) |
68 (76.4) |
11 (68.8) |
G1 vs. G2
G1 vs. G3
G2 vs. G3
G1 vs. control
G2 vs. control
G3 vs. control |
0.13
0.87*
0.73*
0.06
0.72
0.57 |
2.08
1.41
0.68
0.43
0.90
0.61 |
0.79 – 5.49
0.37 – 5.45
0.21 – 2.18
0.18 – 1.06
0.50 – 1.62
0.20 – 1.85 |
| ^– p-value afterBonferroni correction
* – p-value after Yate’s correction
#– global p-value for genotype
Bold indicates a statistically significant differences |
| rs3136176 |
rs1799798 |
| 1 – G1 vs. controls: χ2= 2.880038, df= 2, p= 0.236923 |
7 – G1 vs. controls: χ2= 6.818182, df= 2, p= 0.033148 |
| 2 –G2 vs. controls: χ2= 1.901089, df= 2, p= 0.386531 |
8 – G2 vs. controls: χ2= 0.296027, df= 2, p= 0.862423 |
| 3 – G3 vs. controls: χ2= 10.269320, df= 2, p= 0.005920 |
9 –G3 vs. controls: χ2= 1.251555, df= 2, p= 0.534887 |
| 4 – G1 vs. G3: χ2= 1.053727, df= 2, p= 0.590487 |
10 – G1 vs. G2: χ2= 3.380476, df= 2, p= 0.184581 |
| 5 – G1 vs. G3: χ2= 1.053727, df= 2, p= 0.590487 |
11 – G1 vs. G3: χ2= 1.484755, df= 2, p= 0.476033 |
| 6 – G3 vs. controls: χ2= 4.111672, df= 2, p= 0.042641 |
12 – G2 vs. G3: χ2= 1.046887, df= 2, p= 0.592509 |
