Table 5

	Control group n= 207 n (%)	Cpk n= 33 n (%)	Cpa n= 90 n (%)		ptotal	p	OR	95%CI
rs3136176
*Genotype*
[AA]	116 (56.0)	19 (57.6)	47 (52.2)		ns¹ ns² ns³	referent
[AT]	81 (39.2)	12 (36.4)	32 (35.6)	Cpkvs.Cpa Control vs.Cpk Control vs.Cpa		0.86 0.80 1.00	0.93 0.90 0.98	0.40 – 2.17 0.42 – 1.97 0.57 – 1.66
[TT]	10 (4.8)	3 (6.1)	11 (12.2)	Cpkvs.Cpa Cpkvs. Control Cpavs. Control		0.82* 0.64* 0.03	1.48 1.83 2.71	0.37 – 5.91 0.46 – 7.27 1.08 – 6.82
*Allele*
[A]	313 (75.6)	50 (75.8)	126 (70.0)	Cpkvs.Cpa Control vs.Cpk Control vs.Cpa		0.38 1.00 0.17	0.75 1.02 0.76	0.39 – 1.43 0.56 – 1.87 0.52 – 1.13
[T]	101 (24.4)	16 (24.2)	54 (30.0)	Cpkvs.Cpa Cpkvs. Control Cpavs. Control		0.38 1.00 0.17	1.34 0.98 1.31	0.70 – 2.56 0.53 – 1.79 0.89 – 1.94
*Dominant model*
[AA] + [AT] vs. [TT]	197 (95.2)	31 (93.9)	79 (87.8)	Cpkvs.Cpa Control vs.Cpk Control vs.Cpa		0.83 0.59 0.02	0.70 0.52 0.36	0.18 – 2.66 0.14 – 2.01 0.15 – 0.89
[AA] + [AT] vs. [TT]	10 (4.8)	3 (6.1)	11 (12.2)	Cpkvs.Cpa Control vs.Cpk Control vs.Cpa		0.83 0.59 0.02	1.44 1.91 2.74	0.38 – 5.51 0.50 – 7.32 1.12 – 6.72
*Recessive model*
[TT] + [AT] vs. [AA]	91 (44.0)	15 (42.4)	43 (47.8)	Cpkvs.Cpa Cpkvs. Control Cpavs. Control		0.72 0.87 0.60	1.16 0.99 1.14	0.52 – 2.45 0.48 – 2.06 0.70 – 1.88
[TT] + [AT] vs. [AA]	116 (56.0)	19 (57.6)	47 (52.2)	Cpkvs.Cpa Cpkvs. Control Cpavs. Control		0.72 0.87 0.60	0.86 1.01 0.87	0.39 – 1.91 0.49 – 2.09 0.53 – 1.44
rs1799798
*Genotype*
[GG]	162 (78.3)	22 (66.7)	68 (75.6)		ns¹ ns² ns³	referent
[GA]	42 (20.3)	9 (27.3)	20 (22.2)	Cpkvs.Cpa Cpkvs. Control Cpavs. Control		0.48 0.29 0.68	0.72 1.58 1.13	0.29 – 1.81 0.68 – 3.68 0.62 – 2.07
[AA]	3 (1.4)	2 (6.1)	2 (2.2)	Cpkvs.Cpa Cpkvs. Control Cpavs. Control		0.57* 0.24* 1.00*	0.32 4.91 1.59	0.04 – 2.43 0.78 – 31.03 0.26 – 9.72
Allele
[G]	366 (88.4)	53 (80.3)	156 (86.7)	Cpkvs.Cpa Cpk vs. control Cpavs. Control		0.22 0.07 0.55	1.59 0.53 0.85	0.76 – 3.35 0.27 – 1.05 0.50 – 1.44
[A]	48 (11.6)	13 (19.7)	24 (13.3)	Cpkvs.Cpa Cpk vs. control Cpavs. Control		0.22 0.07 0.55	0.63 1.87 1.17	0.30 – 1.32 0.95 – 3.68 0.69 – 1.98
*Dominant model*
[GG] + [GA] vs. [AA]	204 (98.6)	31 (93.9)	88 (97.8)	Cpkvs.Cpa Cpk vs. control Cpavs. Control		0.62* 0.29* 0.63*	2.84 0.23 0.65	0.38 – 21.02 0.04 – 1.42 0.11 – 3.94
[GG] + [GA] vs. [AA]	3 (1.4)	2 (6.1)	2 (2.2)	Cpkvs.Cpa Cpk vs. control Cpavs. Control		0.62* 0.29* 0.63*	0.35 4.39 1.55	0.05 – 2.61 0.71 – 27.31 0.25 – 9.41
*Recessive model*
[AA] + [GA] vs. [GG]	45 (21.7)	11 (33.3)	22 (24.4)	Cpkvs.Cpa Cpk vs. control Cpavs. Control		0.32 0.14 0.61	0.65 1.80 0.86	0.27 – 1.54 0.81 – 3.99 0.48 – 1.54
[AA] + [GA] vs. [GG]	162 (78.3)	22 (66.7)	68 (75.6)	Cpkvs.Cpa Cpk vs. control Cpavs. Control		0.32 0.14 0.61	1.55 0.56 1.16	0.65 – 3.69 0.25 – 1.23 0.65 – 2.09

^– p-value after Bonferroni correction * – p-value after Yate’s correction; #– global p-value for genotype; rs3136176 1 – Cpk vs. Cpa: χ2= 1.000745, df= 2, p= 0.606335 2 – Cpk vs. controls: χ2= 0.154262, df= 2, p= 0.925770 3 – Cpa vs. controls: χ2= 5.223751, df= 2, p= 0.073497 rs1799798 4 – Cpk vs. Cpa: χ2= 1.615913, df= 2, p= 0.445826 5 – Cpk vs. controls: χ2= 4.057297, df= 2, p= 0.131621 6 – Cpa vs. controls: χ2= 0.394092, df= 2, p= 0.821159

Table 5: ERCC4rs3136176 and ERCC4rs1799798 alleles and genotypes frequencies in cervical squamous cell carcinoma (CSCC): carcinoma planoepitheliale keratodes (Cpk), and carcinoma planoepitheliale aceratodes (Cpa) and healthy women.