KRAS Never Smokers Bone Metastases N=187/224 (83%) N=68/224 (30%) N=32(14%) Mutant: 83/187 (44%) 7/68 (10%) 19 (60%) Wild type: 104/187 (56%) 61/68 (90%) 13(40%)

Table 3: Correlations between KRAS mutation status, smoking and bone metastases