Figure 1: Fine mapping of the chromosomal region 15q15.1-15q21.1 revealed that this region is a common target in FLs and DLBCLs. A) A larger genomic region of 7.5 Mb (hg18.chr15:40190047-47715466) was found to be commonly targeted by copy-loss events across NHL cases, using the False Discovery Rates (FDR) Q-values from GISTIC scores for deletions, previously obtained by Green et al. [7]. B) In addition, it was determined that this commonly deleted region contained 2 LOH regions, LOH-1 region spanning over 3.4 Mb (hg18.chr15:40355785-43764621) and containing 53 genes, and LOH-2 region (hg18.chr15:49759265-50872400) covering a region of 1.1 Mb and harboring 14 genes. Additionally, we observed a third LOH region (LOH-3), which is not further described in this manuscript as it is located outside of the region targeted by copy-loss events. C) Interestingly, the genes TP53BP1 and B2M were identified to be targeted by LOH events in the LOH-1 region. Localization of microsatellites (D15S146 and D15S917) used for validation of the LOH within the region 15q15.1-15q21.1 are indicated.